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23/Oct/2023

From Dr+Vet we are pleased to announce our improvement in the formula of our classic Glauco, the veterinary nutraceutical focused to provide nutrients to the retina and offer neuroprotection to the optic nerve to prevent its degeneration, very relevant in cases of Glaucoma.

Glaucoma is a progressive optic retinopathy and one of the major causes of blindness in humans, it is characterized by optic nerve degeneration, loss of retinal ganglion cells (RGC) and cause restructuring of nerve tissues, causing visual loss.
The factors causing this condition are diverse and complex. Increased intraocular pressure (IOP) has been identified as one of the main drivers of glaucoma and is also the mainstay in the treatment of this disease, focusing on topical and systemic IOP-lowering treatments. Although even though IOP can be effectively controlled, there are patients whose disease still progresses, causing irreversible vision loss.
It is for this reason that Dr+Vet created Glauco+, a nutritional supplement with several natural components that help to generate positive effects on the retina and offer protection against the progression of this disease. Through the incorporation of Citicoline, a molecule that has demonstrated its potential in studies on neurodegenerative diseases, we are opening a door towards a more complete approach to the management of glaucoma in our pets.

Discovering the Potential of Citicoline
In the constant quest to improve treatments for glaucoma in pets, ophthalmic specialists have played a key role in the evolution of therapeutic options. It is for this reason that the incorporation of citicoline in the Glauco+ formula has been a long-awaited and much-requested addition by these eye health experts. Citicoline has garnered considerable attention in the field of neurodegenerative diseases. Research in human medicine has shown its potential benefits in conditions such as senile dementia, Parkinson’s disease and glaucoma. Its introduction in Glauco+ aims to take advantage of these potential benefits for pets.

Citicoline, also known as cytidine-5′-diphosphocholine, is essential for synthesizing membrane phospholipids, including phosphatidylcholine. This compound participates in several metabolic pathways, playing roles in phospholipid homeostasis, mitochondrial dynamics and neurotransmission, especially in the complex mechanism of visual transmission.
When administered orally, Citicoline is efficiently absorbed in the intestines, being transformed into choline and cytidine in the digestive tract and liver. These compounds cross the blood-brain barrier, becoming precursors of vital metabolites. These include phospholipids, nucleic acids, proteins, sphingomyelin, cardiolipin and acetylcholine, a major neurotransmitter in the cholinergic system that modulates visual processes.
In human clinical studies, the ability of citicoline to counteract glutamate-mediated excitotoxicity and oxidative stress, factors that play a crucial role in glaucoma-associated neuronal damage, has been observed. In addition, its influence on the regulation of neurotransmitters such as dopamine and acetylcholine has been linked to improvements in visual function, which translates into a positive impact on quality of life.

Not only has citicoline been shown to protect damaged retinal ganglion cells, but it also acts to improve mitochondrial function and cell membrane integrity. These effects are particularly relevant in the context of glaucoma, where mitochondrial aging processes and neuronal axon damage are characteristic features of the disease.

The classic Glauco components are still present
The Glauco+ approach is based on the combination of natural components, each with its own unique properties and benefits. These components have been selected to address multiple factors, providing a comprehensive solution.
Ginkgo biloba: Native to Asia, this medicinal plant has been appreciated for its properties in traditional medicine for centuries. The extracts of its leaves are rich in flavonoids and terpenoids, which have shown beneficial effects on blood circulation, reduction of blood viscosity, increase in retinal blood flow and neuroprotection.
Anthocyanins (Vaccinium myrtillus, wild blueberry): These natural pigments, present in fruits and vegetables, help improve blood circulation and show antioxidant action. They have an affinity for vascular tissues and have been recognized as beneficial for eye health. Anthocyanins have been shown to contribute to the normalization of retinal blood flow.
Vitamin B3 (Niacinamide or Nicotinamide): This essential vitamin acts as a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD+), vital for mitochondrial function and energy production in retinal ganglion cells. The decrease in NAD+ levels with age and in neurodegenerative diseases, such as glaucoma, has been documented. Supplementation with vitamin B3 has been shown to be a powerful neuroprotectant, preventing neuronal damage and mitochondrial dysfunction.
Vitamin B9 (folic acid) and Vitamin B12 – These B vitamins play a key role in regulating levels of homocysteine, an amino acid linked to retinal damage. The relationship between elevated homocysteine levels and eye damage has been highlighted in several studies. Taking vitamins B12 and B9, in particular, has been associated with reducing homocysteine levels, which could be beneficial in preventing this form of damage.

New tablet format divisible into 4 parts
With the new format divisible into 4 parts, we offer the possibility of adjusting the dose of Glauco+ according to the individual needs of each pet. This new format makes dosing more personalized and precise than with the old format. Offering the possibility of dosing from 2.5kg onwards.
How to get Glauco+?
To purchase Glauco+, you can obtain it exclusively through veterinary distributors in specialized clinics. This measure guarantees that you receive the product under the guidance and supervision of animal health professionals.

In summary
The inclusion of citicoline in Glauco+ represents a step forward in the search for more complete dietary supplements for the eye health of pets. The support and recommendation of ophthalmologists specialized in ocular health are the basis for the development of new and improved products focused especially on veterinary medicine.

From Dr+Vet we want to remember that Glauco+ will be available from November and that at AVEPA-SEVC we will be presenting the product.


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